Psoriasis severity linked to rising risk of abdominal aortic aneurysms

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Psoriasis sufferers may face a higher risk of developing abdominal aortic aneurysms, according to new research in Arteriosclerosis, Thrombosis and Vascular Biology, an American Heart Association journal.

The study also found that the more severe the psoriasis, the greater the risk for abdominal aortic aneurysms.

“Psoriasis must be considered as a systemic inflammatory disease rather than an isolated skin disease. Increased awareness on heightened risk of other cardiovascular diseases, including abdominal aortic aneurysms, in patients with psoriasis is also required,” said Usman Khalid, lead author and PhD fellow in the Department of Cardiology, at Herlev and Gentofte Hospital in Denmark.

Using Danish nationwide registers, researchers identified 59,423 patients with mild psoriasis and 11,566 patients with severe psoriasis between 1997 and 2011. These patients were followed until diagnosis of abdominal aortic aneurysms, death, migration or the study end date. The rates of developing abdominal aortic aneurysms (per 10,000 person-years) were: 

  • 3.72 for general population;
  • 7.30 for patients with mild psoriasis;
  • 9.87 for patients with severe psoriasis.

“Compared to the general population, the adjusted incidence rate ratios were significantly increased for severe psoriasis at 1.67. That is a 67% greater risk of abdominal aortic aneurysm likelihood for severe psoriasis sufferers,” Khalid said. “Clinicians need to educate and assist their patients with psoriasis in lifestyle and risk factor modification to facilitate cardiovascular disease risk reduction.”

Khalid said that the study significantly adds to current evidence of psoriasis as a clinically relevant risk factor for cardiovascular disease and may require further investigation to answer questions, such as whether patients with psoriasis should undergo increased ultrasonic screening for abdominal aortic aneurysms, and whether anti-inflammatory treatment of psoriasis may reduce the risk of the condition.