A range of interventional radiology experts including Michael Dake (Tucson, USA), John Kaufman (Portland, USA), Jim Reekers (Amsterdam, The Netherlands) and Gunnar Tepe (Rosenheim, Germany) give their thoughts on the recently released meta-analysis in JVIR, which has suggested an increased risk of death and amputation at 12 months when paclitaxel-coated balloons are used in the infrapopliteal arteries for the treatment of critical-limb threatening ischaemia (CLTI).