Intergard Synergy vascular graft gets CE mark


Maquet Cardiovascular has announced that it has received CE mark for its Intergard Synergy vascular graft. This graft represents the next generation in antimicrobial grafts combining the well-known antimicrobial properties of silver acetate and triclosan.

Vascular graft infection, although rare, is one of the most serious complications of vascular reconstructive surgery. Conservative treatment of prosthetic graft infections is rarely successful and is used only in patients with a high operative risk or apparently limited infection. Therefore, the most effective strategy against this severe complication is primary prevention of vascular graft infection.

“This new Intergard Synergy uses an interesting approach to fight against acquired infection in vascular surgery patients. The combination of these two well-known and effective antimicrobial agents on the vascular graft is promising. This new infection protection holds the potential to enhance my ability to ensure that my vascular surgery patients remain infection free,” said Max Zegelman, Krankenhaus Nordwest, Frankfurt, Germany. “I have long been an advocate of antimicrobial coatings on surgical prosthesis even though there is not yet evidence-based demonstration of their impact on overall infection rates. I believe Intergard Synergy graft is offering new possibilities.”

The Intergard Synergy graft is designed to help prevent infection by using a combination of the broad spectrum anti-infective properties of silver and triclosan, which are released from the surface of the graft to surrounding tissues following implantation. While silver acetate and triclosan are effective antimicrobial agents alone, their power to prevent development of infection is intensified when combined and offers surgeons a vascular graft with increased antimicrobial properties. In vitro testing of the Intergard Synergy vascular graft demonstrates antimicrobial efficacy against a broad spectrum of micro-organisms including MRSA (Methicillin Resistant Staphylococcus Aureus) and is substantially more effective than the first generation Intergard Silver graft.2


1. In vitro evaluation of the antimicrobial efficacy of a new silver-triclosan vs a silver collagen-coated polyester vascular graft against methicillin-resistant Staphylococcus aureus. Ricco JB, Assadian A, Schneider F, Assadian O. J Vasc Surg. 2012 Mar;55(3):823-9. Epub 2011 Nov 10.